Endocarditis - Division of Cardiovascular Medicine ::

Endocarditis

Faculty

Endocarditis is associated with a high proportion of adverse outcomes, but little high-quality evidence exists to gauge who is at risk, to aid in prevention, or to guide therapeutic decision-making when patients develop infectious endocarditis (IE).

At Duke, we have a substantial history of endocarditis research and a dedicated research team devoted to improving endocarditis patient care and research. The local research efforts focus on the Duke Endocarditis Prospective Cohort Study, the longest running prospective cohort study of its type in the United States.

We also serve as the Coordinating Center for the International Collaboration on Endocarditis (ICE). ICE resources include:

The largest combined (retrospective) database of patients with endocarditis
The first international multicenter prospective cohort study in infectious endocarditis (IE)

In addition, we have established collaborations with leading scientists to examine potential pathophysiologic mechanisms associated with complications in IE.

Selected Publications

F owler VG, Boucher HW, Corey GR, Abrutyn E, Karchmer AW, Rupp ME, Levine DP, Chambers HF, Tally FP, Vigliani GA, Cabell CH, Link AS, DeMeyer I, Filler SG, Zervos M, Cook P, Parsonnet J, Bernstein JM, Price CS, Forrest GN, Fatkenheuer G, Gereca M, Rehn SJ, Brodt HR, Tice A, Cosgrove SE. Daptomycin versus Standard Therapy for Bacteremia and Endocarditis Caused by Staphylococcus aureus. New England Journal of Medicine. 2006;355:653-665.
Cabell CH, Abrutyn E, Fowler VG, Hoen B, Miro JM, Corey GR, Olaison L, Pappas P, Anstrom KJ, Stafford JA, Eykyn S, Habib G, Mestres CA, Wang A. Early surgery may be beneficial only in a targeted population with native valve infective endocarditis: an international, multicenter perspective. American Heart Journal. 2005;150:1092-8.
Fowler VG, Miro JM, Hoen B, Cabell CH, Abrutyn E, Rubinstein E, Corey GR, Spelman D, Bradley SF, Barsic B, Pappas PA, Anstrom KJ, Wray D, Fortes CQ, Anguera I, Athan E, Jones P, van der Meer JTM, Elliott TSJ, Levine DP, Bayer AS. Staphylococcus aureus Endocarditis: A Consequence of Medical Progress. Journal of the American Medical Association. 2005;293:3012-21.
Wang A, Pappas P, Anstrom K, Abrutyn E, Fowler VG, Hoen B, Miro J, Corey GR, Olaison L, Stafford JA, Eykyn S, Mestres CA, Cabell CH. The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort. American Heart Journal. 2005;150:1086-91.
Cabell CH, Heidenreich PA, Chu V, Moore C, Stryjewski M, Corey GR, Fowler VG. Increasing Rates of Cardiac Device Infections Among Medicare Beneficiaries: 1990-1999. American Heart Journal 2004;147:582-6.