Valvular, Hemodynamic, and Adult Congenital Research - Division of Cardiovascular Medicine ::

Valvular, Hemodynamic, and Adult Congenital Research

J. Kevin Harrison, MD

Faculty

Thomas R. Gehrig, MD
Thomas Bashore, MD
Andrew Wang, MD

This research program is focused primarily on non-coronary artery diseases. A large and established balloon valvuloplasty program is supplemented by:

A large program in both primary and secondary pulmonary hypertension
The investigation of a variety of closure devices and stents
The use of alcohol ablation for hypertrophic cardiomyopathy
An interest in angiographic imaging
Evaluation of complex hemodynamics

A recent clinical trial showed that the AngelWings device, developed at Duke for percutaneous closure of the atrial septal defects, is effective and safe 4-7 years post-procedure.

Cooperative projects involve the Cardiovascular Magnetic Resonance Center, the invasive pediatric cardiology group, nuclear cardiology, the echocardiographic laboratory, cardiothoracic surgery, electrophysiology, and the endocarditis service.

Patients are primarily referred for novel interventional procedures or from the pulmonary hypertension/lung transplantation centers at Duke. The majority of patients are on the Duke Heart Physicians service.

Selected publications

Wang A, Krasuski RA, Warner JJ, Pieper K, Kisslo KB, Bashore TM, Harrison JK. Serial echocardiographic evaluation of restenosis after successful percutaneous mitral commissurotomy. J Am Coll Cardiol 2002;39:328-334.
Krasuski RA, Bush A, Kay JE, Mayes CE, Wang A, Fleming J, Pierce C, Kisslo KB, Harrison JK, Bashore TM. C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral commissurotomy. Am Heart J 2003;146:1099-104.
Wang A, Holcslaw T, Bashore TM, et al. Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism. Kidney Int 2000;57:1675.
Krasuski RA, Wang A, Ross C, Bolles JF, Moloney EL, Kelly LP, Harrison JK, Bashore TM, Sketch M Jr. Trained and supervised physician assistants can safely perform diagnostic cardiac catheterization with coronary angiography. Cath Cardiovasc Intervent 2003;59:157.
Bashore TM, Gehrig T. Cholesterol emboli after invasive cardiac procedures. J Am Coll Cardiol 2003;42:217.
Krasuski RA, Assar MD, Wang A, Kisslo KB, Pierce C, Harrison JK, Bashore TM. Usefulness of percutaneous balloon mitral commissurotomy in preventing the development of atrial fibrillation in patients with mitral stenosis. Am J Cardiol 2004;93:936-939.
Kay JD, O'Laughlin MP, Ito K, Wang A, Bashore TM, Harrison JK. Five-year clinical and echocardiographic evaluation of the Das AngelWings atrial septal occluder. Am Heart J 2004;147:361-368.
Krasuski RA, Bush A, Kay JE, Mayes CE Jr, Wang A, Fleming J, Pierce C, Kisslo KB, Harrison JK, Bashore TM. C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy. Am Heart J 2003;146:1099-1104.